Top similar games like Isolate ME!:
Isolate ME! $2.99
An exciting survival game with roguelike elements in which you have to play as a police officer in a city engulfed by a pandemic, look for infected people and isolate them, manage the budget and hire police officers, set up vaccination centers and propaganda stands.
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Breachwalk Survivor$2.99
Breachwalk Survivor is a single-player game combines survivor genre with inventory management. Before sneaking into another dimension, it’s better to plan which weapons to craft and strategize the path. Stealing just one 'World Core' will save your world, but there’s still extra space in your bag...
MEATGUN$4.99
The top-down roguelike shooter where your ammunition is edible. Delve into The Facility and fight off hordes of mutant vegetables with your MEATGUN: Shoot meat to damage enemies, and eat meat to heal. Collect various items and combine their effects to become a powerful, veggie-killing machine.
Battle for the Crystals$1.99
Prepare for a relentless battle in "Battle for the Crystals," a homage to the classic multidirectional shooters that demand skill and strategic prowess. Combining action RPG and auto-battler mechanics, Battle for the Crystals brings you minimalistic yet very challenging fantasy battlefields.
Nebula$3.99
Survive in the deep void of the galaxy against thousands of invaders! Nebula is a challenging bullet hell, twin stick shooter where you have to face endless waves of space enemies. Additional map resources and space drones can provide you a support but be wary, they can as well become a deadly trap.
RymdResa$11.99
A relaxed roguelike space odyssey in a procedurally generated universe! Travel through a lonely and mysterious cosmos. Customize your ship, explore and survive!
CAN BULLET$3.99
BANG BANG BANG! CAN BULLET has come to your PC! Just shoot the cans and get rid of yesterday's, today's, and tomorrow's frustrations. A simple roguelike shooter, also good for a mid-afternoon coffee break.
Melt Them All$1.99
Melt them All is action rogue-lite where you must survive as long as possible to maximizing your energy production in the process. Automate the resource collection and upgrade buildings and weapons to kill, mine and produce even more effective.
Heat Signature$14.99
Heat Signature is a game from the developers of Gunpoint where you break into spaceships, make terrible mistakes, and think of clever ways out of them. You take a mission, fly to the target ship, sneak inside, and make clever use of your gadgets to distract, ambush and take out the crew.
Colorfire ReduxFREE
Well, the physpace is being destroyed, glitching by numerous hordes of malicious duplicating codes from the bitspace. People are panicking, we must send our final attempt to fix the issue, you must be trained to fix the bitspace and survive in it during the process, in its current, decaying status.
Anx Defense$9.99
Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.
ReCoilFREE
ReCoil is a 2D Top-Down Shooter with a unique twist to it's genre. The recoil of your weapons launches you back.
Balloons$4.99
Balloons is a single-player 2D racing game with roguelite elements. You can play as different emotive head balloons, breathe to gain lift, and enjoy fun and challenging tracks. The game has random map generation, different skill combinations. Win by reaching the finish line first.
Tetron$5.99
Tetron is a 1-bit, top down, atmospheric, twin stick action roguelite with a unique perk based upgrade system, a wide variety of enemies, depthful combat, and distinct procedural levels.
Ricochet Ranger$4.99
A Shooter Game With One Bullet.
Bad Writer$5.99
I decided to chase my dream and try to make it as a writer. I have the support of my wife Cleo, and enough savings for a month. After that, we'll see what happens. But I know I can do it! I just need to stick with writing and submitting short stories each day.
Hookscrap$0.99
Fight as the owner of Hookscrap in a thrilling 2D rogue-like. Unleash the power of your Harpoon, by launching ships & asteroids at enemies. Upgrade your ship with loot from your foes, and become even stronger. Explore 5 unique levels in a randomly generated map & take down the fearsome SC Judgement!
EternaMine$4.99
Mine, fight monsters, upgrade your gear, obtain rare items, unlock new powers and mine some more in the massive follow-up to the popular title "Haste-Miner 2". Eternamine offers a casual yet engaging gameplay experience, expand your mining empire and discover the secrets that lie beneath the earth.
Mayhem Survivors: AnimalsFREE
Mayhem Survivors is an action rogue-like game, where you feed cute animals with various different foods in order to Survive. It is inspired by Survivors-like games and features 3 different game modes.
Asteroids Maneuvers$0.99
Maneuver through Asteroids and collect Juice!
Cards and Guns$6.99
Cards and Guns is a top-down arena shooter roguelite, where you’ll have to defeat hordes of creatures. Choose from a variety of cards and upgrades to create unique builds and survive to the end.
I HATE (other) Animals!$0.99
I HATE (other) Animals! is a reverse bullet hell game with roguelite elements with focus on exciting loot in a survivors-like setting. Collect loot during each run and buy permanent upgrades to your characters to make the next run a bit easier.
1000 Seconds$2.99
1000 Seconds is a roguelike – Defeat enemies, gather resources, and upgrade your orb to escape the temporal limbo, but you only have 1000 seconds to reach the end, so be as fast as possible.
Infectonator: Survivors$9.99
"Infectonator : Survivors" is a Randomized Permadeath Survival Simulator that combines RTS, Tower Defense, Roguelike, and Management-Simulation gameplay. The goal is to lead a group of survivors in a struggle to stay alive and find rescue in a zombie apocalyptic world.
Keplerth$14.99
Welcome to Keplerth! Try to survive on a hostile alien planet in this 2D sandbox RPG, where you can choose to live alone or fight side by side with your friends in the online multiplayer mode. Survive, build, farm, fight, and explore your way to victory in this open-world adventure!
Space Bot$4.99
Space Bot is a strategic action roguelite where your environment is fully desctructable, and out to get you. Destroy planets with your giant mining drill, and fight off dangerous alien lifeforms
Mullet Hell$2.99
Blast your way through hair curling enemies to prove you are worthy of the mullet! Mullet Hell is a casual rogue-like, reverse bullet hell where you must fend off foes who seek to remove your luscious locks from your head.
Floops Big House Adventure$4.99
Shoot, loot, and toot your way through Saturday morning cartoon inspired Floops Big House Adventure! This love letter to 90's and Nickelodeon cartoon style will have you rolling with laughter as you defeat hordes of evil monsters and giant disgusting bosses.
Scrap Bastion$4.99
Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!
Pixel Art - Mash-Up$0.99
Level up your skills while fighting your way through waves of chaos. Levels are generated at the start of every game and will be different each time you play.
GhostGame$7.99
GhostGame is the roguelike bullet hell game that puts your hand-mouse coordination to the test. Fight through hordes of enemies, gain powerful skills, acquire companions and defeat bosses to accomplish your ultimate mission.
Deadly Days$11.99
Deadly Days is a unique strategic rogue-lite in the zombie apocalypse. Manage and protect a group of survivors and help them to stop the catastrophe. Discover and use a large number of wild and crazy objects, even wilder and crazier survivors, special abilities, and deadly weapons.
The Story Goes On$4.99
You are the hero inside the storybook of an obsessed author pondering with his life’s work. Explore repeating worlds, befriend a talking scarecrow and swing your sword really fast, while uncovering the true, overarching adventure within.
Modest Kind$3.99
Modest Kind is a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your Path to Enlightment begins now.
NecroBouncer$13.99
Happy hour has arrived! Become the NecroBouncer and toss out rowdy guests in a roguelike adventure through the nightclub dungeon. Raise the dead, discover hundreds of relics, ban enemies and gobble up their powers. It’s one hell of a good time!
Impeachment Survivors$2.99
Survive the Impeachment! Impeachment Survivors is a political parody action roguelike with many waves of enemies, upgrades, and comedy. Be hypocrite, be corrupt, be a politician!
KaiserFREE
Go on a campaign to dethrone the kaiser! Build an army, strengthen yourself with powerful artefacts and defeat the forces he sends to stop you. Kaiser is a casual roguelike game where you fight thousands of enemies in an attempt to become the new kaiser.
bugTDX$2.99
Buy, sell, and merge towers in this tower defense roguelike inspired by Bloons TD6 and Super Auto Pets. With 40+ towers and 15 enemy types, this chill tower defense game provides hours of fun replayability!
Edge Of Galaxy$4.99
Edge of Galaxy is a real-time tactical space sim with RPG-lite elements. As the commander of a mercenary fleet, you must hire and manage your ships, upgrade their capabilities, and rise through the ranks to become a legend among mercs.
Ikki Unite$11.99
SUNSOFT relapses... The legendary Bad Game Hall of Famer "Ikki" is back, and this time it's a multiplayer experience! You can't start a riot with just one or two people! Enlist up to 16 friends in this Roguelite madness... Ikki but united!
Police Heroes$2.99
Use multiple heroes, each with their own choices, abilities and play style to defeat the zombie apocalypse! Play several stages in different locations, against hordes of increasingly stronger and more dangerous zombies. All this with a unique mechanic where damage equals money!
To Your Stations!FREE
To Your Stations! is a couch co-op spaceship management game where up to four players work together to crew a spaceship. Coordinate the torpedoes, lasers, and shields of your ship to fight off asteroids, aliens, and other deep space entities.
Valley of The Savage RunFREE
Move both frogs in sync to reach the end of the level before the predator catches them. Can you use your brain's left and right hemispheres simultaneously to move the frogs in sync? Only 5% are able to do it.
Beats of Betrayal$11.99
Beats of Betrayal is an adventure game with roguelike mechanics and rhythm-based combat. Explore dungeons, gain skills and grow stronger to defeat challenging bosses and unlock the secrets surrounding the 'Power of the Waves'!
Grym Wonder$4.99
Fight tirelessly in the world of the game Grym Wonder, created in the style of power-fantasy with rogue-lite elements, where you are one on one with thousands of monsters and their leaders.
Castle of no Escape 2$4.99
Explore 6 x 6 x 6 = 216 rooms of randomly generated hazards and enemies while collecting the necessary artefacts. Hundreds of monsters are roaming inside, guarding the sword shards — the last known thing to be capable of defeating the demonic castle owner.
Castle Break$4.99
Breakout game + physics + shooting + building. Use your mouse like in air hockey to kick enemy bombs back into the evil Black Castle! Destroy enemy towers rockets and lasers. Build your base to protect your little dudes - you need them to win
Save and Conquer : 8 YearsFREE
This is a 2D defense game that depicts the near future that may arise from climate change. Unlike the defense game, which is automatically attacked by traditional turrets, it is an attractive game that requires you to defeat the enemy by operating the turret directly with limited power.
Apple Run$2.99
A fun twist on the classic video game 'snake'! You are a free roaming snake collecting apples and avoiding lava. Complete challenges, customize your snake and unlock achievements. What is the maximum score you can get?
Pest Control in the Crypt$2.99
Pest Control in the Crypt is a strategic rogue-like wave-battler. Enhance your elemental potions with unique items and a branching skill tree to slay Pests. Delve into the Abyss and conquer the Crypt.
Meme Survivors$0.99
Meme Survivors is a casual game with a vibrant visual style predominantly made up of popular memes, featuring simplified roguelike elements. Waves of Cheems, Doge, and other enemies face off against Pop Cat and his friends!
The Help Desk$2.99
Do you think you can go all the way?