Top similar games like The Last Experiment: A Memetric Story:
The Last Experiment: A Memetric Story $15.99
After the technological singularity, the world lies in ruin. The surface is overrun by a parasitic species, devouring all it touches. An underground team of scientists works to develop resistant lifeforms to reclaim the world – but they need a brave scout to face the dangers above.
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Rise to Ruins$14.99
A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.

Decision: Red Daze$19.99
Decision: Red Daze is an action RPG with a unique mix of survival and tower defense mechanics. Explore an apocalyptic wasteland, build a safe haven, and lead your team of specialists in a hopeless world, searching for a cure for the infectious disease that turns people into monsters.

Ghostboy$9.99
Would you return from death to help your loved ones through grief? Make fate turning decisions, micromanage the family’s relationships and defeat the negative thoughts on tower defense levels. Watch out, your job will be harder the more severe their mental disorder is.

Alien Hallway$4.99
Players measure stamina with a never-ending stream of green creatures within the borders of a special military mission.

After the Collapse$14.99
ATC is a base building game set in a post-apocalyptic world featuring urban environments. Build a base across several layers with dozens of survivors. Fight other factions for the control of the remaining production centers and explore the world to find long forgotten resources and technologies.

The Last Spell$24.99
Defend the last bastion of humanity with your squad of heroes! Exterminate fiendish monsters with magic and brute force by night and re-build your battered city defenses by day in this tactical RPG with rogue-lite mechanics.

Defender Bros$10.99
Prepare your defenses during the day and survive until dawn. Defender Bros is a Top-Down Tower Defense Roguelike where you play as a Soldier defending your Base. Pick between multiple abilities as you level up to increase you power, then after each run buy perks and get stronger

Sheltered 2$19.99
A brutal survival management simulator set in a post-apocalyptic wasteland. Keep your faction of survivors alive, maintain your shelter and scavenge the ravaged world for resources. Befriend and trade with the factions you meet or conquer them by force.

bugTDX$2.99
Buy, sell, and merge towers in this tower defense roguelike inspired by Bloons TD6 and Super Auto Pets. With 40+ towers and 15 enemy types, this chill tower defense game provides hours of fun replayability!

Kainga: Seeds of Civilization$19.99
Welcome to the mystical world of Kainga, an unusual roguelite village-builder! Take control of a Thinker and, with the help of your people, grow a unique town to complete short challenges while discovering the world and adapting to the pressures of the environment, beasts and other tribes.

Basement$19.99
Basement is a strategy game, where you start doing illegal business to fund the development of your dream video game. It won't be easy, so get ready to deal with other gangs, cops, crazy junkies, mysterious investor and even ghosts from the past.

Anx Defense$9.99
Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

BARRICADEZ$18.99
Barricadez is a mix of tower defense and survival game. Take on your care robot and explore the underground, find new blueprints, gather resources and build your defenses and traps to survive through the night against a myriad of zombie-like creatures. Your goal: to defend the defenseless cradle.

Space Station Continuum$14.99
Space Station Continuum is a building & management sim inspired by the past, present, and future of humans in space.

Guardener$4.99
An arcade strategy game about defending your garden. Grow potatoes, onions and carrots to defend your lawn!

Bulwark$6.99
Bulwark is a medieval-themed 2D pixel tower defense game with a dynamic block-based building system. Construct and fortify your castle, manage resources, and recruit troops to defend against waves of enemies. Build, strategize, and adapt in this unique blend of fortress construction and combat.

SimAirport$24.99
Build & Manage Your Airport. An International Hub or a Regional Masterpiece -- it's up to you. Buy more land to scale out, or escalators to scale up with MULTIPLE FLOORS. You're in full control in this modern business management tycoon!

They Are Coming$2.99
They Are Coming is a hybrid game that combines roguelike, tower defense, and base building in a side-scrolling shooter format. It offers a straightforward gaming experience for pure enjoyment.

Judgment: Apocalypse Survival Simulation$19.99
Build, scavenge, craft, and perform occult rituals to survive in a demon-infested, post-apocalyptic colony simulation. Will you survive Judgment day?

Cepheus Protocol$19.99
Cepheus Protocol is an Open World RTS Military Survival Game. Play as the CERC hunting Patient 0, maintain Quarantine camps, fight dangerous mutations & Rogue Civilian Combatants . There’s nobody else coming, it’s up to you now.

Odd Realm$19.99
Dive into Odd Realm, a mystical colony sim set in a land of fantasy! Lead your settlers to construct a thriving haven, navigating unpredictable seasons, elusive bandits, unseen horrors, and fabled gods. Every choice etches your colony's destiny, igniting a saga of adventure, peril, and triumph.

Rotten Tide$5.99
Rotten Tide is a horizontal 2D tower defense game where players must protect the world from the attacks of all kinds of monsters who are threatening the humans in big cities all around the world.

Phoenix Hope$11.99
Phoenix Hope is a pixel art 2D real-time, side-view strategy game in which you must develop your colony during the day and repel waves of monsters at night.

Dwarfs!?$9.99
Dig! Dig! Dig! Manage the small underground Dwarf base and make it as rich as possible before they meet their inevitable doom. Purchase before May 11th and save!

These Doomed Isles$14.99
Harvest cards to raise land from the sea, build settlements and rain fire upon invaders in this survival city-builder with roguelike deckbuilding mechanics. Choose from 4 gods with unique cards, playstyles and abilities to lead their civilisations to victory in strategic run-based gameplay!

Kairobotica$8.99
Vanquish villains and lead the Kairobot Corps to glory in this spacefaring saga!

Acid Planet$9.99
Acid Planet is a caustic blend of horde-survival, tower-defense and strategy. Build, fight and evolve to survive against rampaging swarms of monsters and fearsome Kaiju.

Wall World$6.99
Explore the mysterious Wall World on your giant robospider: mine for valuable resources, upgrade your equipment to fight off hordes of monsters, and discover exotic biomes in-between attacks. Will you be able to survive and learn the secrets of the Wall World?

IXION$34.99
IXION is an unrelenting, city-building odyssey across the stars. As Administrator of the Tiqqun, DOLOS’ prototype space station, you are tasked with balancing preservation and exploration as you manage infrastructure, resources and crew. Can you keep the flame of humanity alight in the cold dark?

Illumina Defender$4.99
Defend the vibrant world of Illumina from descending enemies in this retro-styled, fast-paced, single-player arcade game. Utilize strategic upgrades to keep the city safe and enjoy an electrifying soundtrack while you do it!

Homeseek$24.99
Homeseek is a post-apocalyptic survival strategy game set on a resource-strapped Earth at the turn of the next century. In a dried-up wasteland where water has become the new gold, every choice you make becomes life or death.

Halcyon 6: Starbase Commander$14.99
Halcyon 6: Starbase Commander is a retro space strategy RPG with base building, deep tactical combat, crew management and emergent storytelling.

Brave Path$4.99
Classical turn-based roguelike with crafting and base building.

Starmancer$14.99
From a small 2-man team comes a unique space station management sim. Take on the role of an A.I commanding a lost space ark. Try not to let your crew run amok and wreck the place.

Chrysalis$9.99
Defend your Chrysalis from growing hordes of monsters in this hybrid game that combines elements of tower defense, survival, and roguelike RPGs. Explore procedurally generated levels, possess and control animals, and grow deadly gardens. How far can you get before the next wave of monsters?

The Last City$4.99
"Survive and thrive in the desert! Lead a group of colonists, build a thriving colony, gather resources, craft tools, and research technologies in 'The Last City' - a challenging survival strategy game."

Craft In Abyss$9.99
Craft in Abyss is a tower defense rogue-lite game. It allow players to design their own mechanical fortress, gather resources and continuously strengthen the fortress facilities within a sci-fi world.

Memetric: Classic$13.99
It's a "side-scrolling" real-time strategy game, pixelart style, with a few small "rouge-lite" elements. You have to collect and farm creatures, various bizarre creatures, to further develop your territory and eventually defeat the evil force that has been organizing against you throughout the game.

Off Course ELEMENTS of SPACE$9.99
2d pixel art, top down sci- fi space ship building, resource management simulation with some arcade, tower defense elements. You build spaceship, collect necessary resources and defend yourself against waves of enemies. Equip ship with: rockets, life support, electric system and weapons.

March of the Living$14.99
Roguelike-like inspired by FTL and popular zombie fiction. Guide a group of survivors to a rumoured safe haven.

Secret Summoner$7.99
A young fledgling hero sets out on a journey to teach misbehaving monsters a lesson. But little does he know his own mother tags along to support the youngster from the shadows in this action puzzle game!

Creeper World 3: Arc Eternal$14.99
Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Memetric: Final Lifeforms$12.99
The game has a main gameplay based on sidescrolling strategy set in a sci-fi world. The goal of our protagonists is to restart life on the planet after an extinction.

Loopstructor$4.99
This is a strategy game that combines tower defense with Roguelike. Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defense loop and build battle trains to defend against enemy attacks.

This War of Mine$19.99
In This War Of Mine you do not play as an elite soldier, rather a group of civilians trying to survive in a besieged city; struggling with lack of food, medicine and constant danger from snipers and hostile scavengers. The game provides an experience of war seen from an entirely new angle.

Jumbo Airport Story$8.99
Just imagine: your own world-famous airport! A game with sky-high levels of fun!

Hexton$1.99
Explore, build, harvest. Hexton is a relaxing building game where you try to create the largest city possible. Looking for a light challenge? This game's for you!

Lazy Galaxy 2$7.99
Lazy Galaxy 2 is an idle/clicker game with base-building and RTS elements. Lead an evil (albeit lazy) alien race to conquer the universe! Expand your base, fight vicious foes, and conquer the galaxies. Acquire combat experience and convert into candy, the most precious alien resource!

Destroy The Monoliths$6.99
Explore. Mine. Build. Fight. Destroy The Monoliths is a single-player real-time mining tower offense roguelike where you explore a randomly generated map, mine the terrain to get resources, and build turrets to both protect your base and fight monoliths that keep spawning ever more minions.

Drill to the Stars$14.99
In "Drill to the Stars," you build your OWN base! Guide enemies with walls into traps and eliminate them before they destroy your drill. Strategically adapt to the environment and place the towers cleverly for maximum attack speed in this roguelite tower defense game.

Crimson Connect Origin$5.99
Survive, collector's heroes!! game is a fusion genre of real-time strategy and roguelike. Survive to the end through defense-style battles